ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Persistent splenic visualization on technetium-99m DISIDA hepatobiliary studies | JoVE Visualize

Home
Research Domains
Mathematical Sciences

Persistent splenic visualization on technetium-99m DISIDA hepatobiliary studies

J Balseiro¹, M J Fratkin, J I Hirsch

¹Veterans Administration Medical Center, Richmond, Virginia 23249.

Clinical Nuclear Medicine|April 1, 1990

View abstract on PubMed

Summary

Persistent splenic visualization during technetium-99m DISIDA imaging is more common than previously thought. This finding may be linked to elevated levels of reduced, hydrolyzed technetium (colloid) in the radiopharmaceutical.

Area of Science:

Nuclear Medicine
Diagnostic Imaging
Hepatobiliary System

Background:

Technetium-99m DISIDA (diisopropyl iminodiacetic acid) is a radiotracer used for hepatobiliary scintigraphy.
Spleen visualization on DISIDA scans is typically limited to the blood pool phase.

Purpose of the Study:

To evaluate the frequency of persistent splenic visualization during Tc-99m DISIDA imaging.
To investigate potential correlations with patient demographics and diagnoses.

Main Methods:

Retrospective review of 245 Tc-99m DISIDA examinations from two institutions.
Quality control of radiochemical purity using sephadex gel column chromatography.

Main Results:

Persistent splenic visualization occurred in 1.0% of patients at Institution #1 and 7.3% at Institution #2.
No correlation was found between persistent visualization and patient age, sex, or final diagnosis.

Conclusions:

Persistent splenic visualization on Tc-99m DISIDA scans is more frequent than generally acknowledged.
Elevated concentrations of reduced, hydrolyzed technetium (colloid) may cause persistent splenic visualization.

Stochastic Analysis And Modelling

Persistent Splenic Visualization On Technetium-99m Disida Hepatobiliary Studies