CHIP as a therapeutic target for neurological diseases | JoVE Visualize

CHIP as a therapeutic target for neurological diseases

Shuo Zhang^1,2,3, Zheng-Wei Hu^1,2,3, Cheng-Yuan Mao^1,2

¹Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450000, Zhengzhou, Henan, China.

Cell Death & Disease|September 10, 2020

View abstract on PubMed

Summary

Carboxy-terminus of Hsc70-interacting protein (CHIP) is crucial for protein quality control and implicated in neurological diseases. Targeting CHIP may offer new therapeutic strategies for conditions like stroke and Alzheimer's disease.

Area of Science:

Neuroscience
Molecular Biology
Biochemistry

Background:

Carboxy-terminus of Hsc70-interacting protein (CHIP) acts as a co-chaperone and E3 ubiquitin ligase.
CHIP regulates the degradation of misfolded proteins and is involved in various cellular processes like autophagy and immunity.
Ubiquitous expression of CHIP in the central nervous system suggests its role in neurological functions and diseases.

Purpose of the Study:

To review the molecular mechanisms underlying CHIP's role in neurological disease pathogenesis.
To explore CHIP's involvement in stroke, intracerebral hemorrhage, Alzheimer's disease, Parkinson's disease, and polyglutamine diseases.
To discuss the potential of CHIP as a therapeutic target for neurodegenerative disorders.

Main Methods:

Literature review of existing studies on CHIP and neurological diseases.
Analysis of molecular pathways involving CHIP in protein degradation and cellular stress.
Synthesis of evidence highlighting CHIP's dual role in disease pathogenesis and potential therapeutic applications.

Main Results:

CHIP plays a pivotal role in the pathogenesis of various neurological conditions.
CHIP mutations can directly cause neurodegenerative diseases.
Evidence suggests CHIP's involvement in both protective and detrimental roles in neurological disease progression.

Conclusions:

CHIP is a key regulator in the central nervous system with significant implications for neurological health.
Understanding CHIP's multifaceted roles is essential for developing effective treatments for neurodegenerative diseases.
CHIP modulation, particularly overexpression, presents a promising therapeutic avenue for treating neurological disorders.