3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling | JoVE Visualize

3D printing in personalized drug delivery: An overview of hot-melt extrusion-based fused deposition modeling

Nagireddy Dumpa¹, Arun Butreddy¹, Honghe Wang¹

¹Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

International Journal of Pharmaceutics|March 22, 2021

View abstract on PubMed

Summary

Three-dimensional printing (3DP) offers personalized pharmaceutical therapies. Fused deposition modeling (FDM) 3DP, using filaments prepared by hot-melt extrusion (HME), enables customized drug dosage forms with precision and complex designs.

Area of Science:

Pharmaceutical Technology
Materials Science
Biomedical Engineering

Background:

Personalized medicine is advancing rapidly.
Three-dimensional printing (3DP) offers a novel approach to manufacturing customized pharmaceutical dosage forms.
Fused deposition modeling (FDM) is a versatile 3DP technique suitable for pharmaceutical applications.

Purpose of the Study:

To review the process of fused deposition modeling (FDM) 3D printing for pharmaceutical dosage forms.
To discuss the preparation of feedstock filaments using hot-melt extrusion (HME).
To explore the design, characterization, applications, and future of FDM 3D printing in pharmaceuticals.

Main Methods:

Filament preparation using hot-melt extrusion (HME).
Digital design of pharmaceutical dosage forms.
Fused deposition modeling (FDM) 3D printing process.
Filament characterization techniques.

Main Results:

FDM 3DP allows for precise control over drug dosage and complex dosage form designs.
Hot-melt extrusion (HME) is effective for creating pharmaceutical-grade filaments for FDM.
The review covers feedstock preparation, digital design, characterization, and applications.

Conclusions:

FDM 3D printing, combined with HME, presents a promising platform for personalized pharmaceutical manufacturing.
This technology enables the creation of customized dosage forms with enhanced therapeutic potential.
Further research into novel applications and process optimization is warranted.