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Therapeutic and diagnostic relevance of Crispr technology | JoVE Visualize

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Therapeutic and diagnostic relevance of Crispr technology

Ibtissem El Ouar¹, Abdelhamid Djekoun¹

¹University Frères Mentouri Constantine, 1. Road Ain El Bey, Constantine 25000, Algeria.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie|March 28, 2021

View abstract on PubMed

Summary

The CRISPR-Cas system, a bacterial defense mechanism, has become a revolutionary tool for precise genome editing. This review explores its biomedical applications and ethical considerations.

Area of Science:

Molecular Biology
Genetics
Biotechnology

Background:

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a prokaryotic immune system.
The CRISPR-Cas system utilizes a Cas endonuclease guided by RNA to target and cleave specific DNA sequences.
Its discovery in 2007 revolutionized genetic engineering.

Purpose of the Study:

To review current knowledge on the CRISPR-Cas system.
To synthesize its applications in the biomedical field.
To discuss its potential in biological research and disease treatment.

Main Methods:

Literature review of CRISPR-Cas system research.
Analysis of CRISPR-Cas applications in various biomedical domains.
Discussion of ethical implications.

Main Results:

CRISPR-Cas is a powerful and precise tool for targeted genome editing.
Applications include advancing biological mechanism comprehension, treating genetic diseases, controlling microbial virulence, and generating animal models.
Ethical concerns regarding its use in living organisms are significant.

Conclusions:

The CRISPR-Cas system offers transformative potential in biomedicine and research.
Further research and ethical deliberation are crucial for responsible application.
This technology promises significant advancements in healthcare and biological understanding.

Keywords:

Distributed Computing And Systems Software

Dependable Systems

Therapeutic And Diagnostic Relevance Of Crispr Technology