Annexin Animal Models-From Fundamental Principles to Translational Research | JoVE Visualize

Annexin Animal Models-From Fundamental Principles to Translational Research

Thomas Grewal¹, Carles Rentero^2,3, Carlos Enrich^2,3

¹School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.

International Journal of Molecular Sciences|April 3, 2021

View abstract on PubMed

Summary

Genetically modified mouse models reveal annexin protein functions under stress. This research highlights their potential for understanding human diseases and advancing experimental medicine.

Area of Science:

Biomedical Research
Genetics
Molecular Biology

Background:

Annexins are calcium- and lipid-binding proteins with diverse cellular roles.
In vitro studies extensively assessed annexin functions, but in vivo data from deficient models were limited.
Annexin-deficient mice typically show no obvious phenotypes under normal conditions.

Purpose of the Study:

To provide a comprehensive overview of annexin research using animal models.
To explore the phenotypes of genetically modified annexin mouse models under stress conditions.
To discuss the future applications of annexin research in biology and experimental medicine.

Main Methods:

Review of studies involving genetically modified annexin mouse models.
Analysis of phenotypes observed in annexin-deficient mice, particularly under stress.
Synthesis of current knowledge on annexin functions in vivo.

Main Results:

Annexin-deficient mouse models often display striking phenotypes when exposed to stress conditions mimicking human diseases.
Studies reveal the importance of annexins in cellular functions previously underestimated by in vitro data.
Genetically modified models are crucial for uncovering in vivo roles of annexins.

Conclusions:

Annexin mouse models are valuable tools for investigating complex biological processes and disease mechanisms.
Understanding annexin functions in vivo, especially under stress, is critical for translational research.
This review underscores the future potential of annexin research in experimental medicine and biology.