LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system

Area of Science:

• Genomics
• Bioinformatics
• Molecular Biology

Background:

• The initial LncRNAWiki database, while expanding, lacked structured data management.
• Its MediaWiki foundation limited systematic exploration of human long non-coding RNAs (lncRNAs).

Purpose of the Study:

• To present LncRNAWiki 2.0, an improved knowledgebase for human lncRNAs.
• To enhance data organization, curation, and user accessibility for lncRNA research.

Main Methods:

• Re-architected the database using MySQL/Java for structured data management.
• Implemented a new curation model with expanded annotation categories.
• Integrated user-friendly interfaces and online tools for data retrieval and visualization.

Main Results:

• LncRNAWiki 2.0 now contains 2512 human lncRNAs and 1106,242 associations.
• Data includes links to disease, function, drugs, interactions, and CRISPR design.
• Enhanced database and curation model facilitate systematic lncRNA exploration.

Conclusions:

• LncRNAWiki 2.0 provides a comprehensive, structured, and up-to-date resource for functionally annotated human lncRNAs.
• The improved platform supports advanced data curation, retrieval, and visualization for researchers.