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The STIM1 Phosphorylation Saga | JoVE Visualize

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Information And Computing Sciences

The STIM1 Phosphorylation Saga

Fang Yu¹, Khaled Machaca¹

¹Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Doha, Qatar.

Cell Calcium|February 26, 2022

View abstract on PubMed

Summary

Store-operated Ca2+ entry (SOCE) relies on STIM1 and Orai1. While STIM1 phosphorylation affects metabolism, its physiological role in other cellular processes remains unclear.

Area of Science:

Cell Biology
Molecular Physiology
Calcium Signaling

Background:

Store-operated Ca2+ entry (SOCE) is a crucial calcium influx pathway in metazoans.
Defects in SOCE are linked to immunodeficiencies and muscle disorders.
The core SOCE machinery involves the ER calcium sensor STIM1 and the plasma membrane channel Orai1.

Purpose of the Study:

To review the role and modulation of STIM1 phosphorylation.
To critically evaluate the physiological significance of STIM1 phosphorylation in various cellular contexts.

Main Methods:

Literature review of studies on STIM1 phosphorylation.
Analysis of STIM1 phosphorylation's involvement in cellular metabolism, cell division, and migration.
Assessment of controversial findings regarding STIM1 phosphorylation's functions.

Main Results:

STIM1 is a phosphoprotein, often hyper-phosphorylated during cell division.
STIM1 phosphorylation has been implicated in modulating cellular metabolism, SOCE during M-phase, ER segregation, SOCE levels, and cell migration.
The precise physiological role of STIM1 phosphorylation in most of these processes is debated.

Conclusions:

STIM1 phosphorylation clearly modulates cellular energy metabolism.
Except for its role in metabolism, the physiological function of STIM1 phosphorylation remains largely uncertain and requires further investigation.

Keywords:

Information Systems

Information Security Management

The Stim1 Phosphorylation Saga

Endoplasmic Reticulum

Phosphorylation

Serine/threonine

Store operated Ca entry