Effect of continued ultraviolet B phototherapy on the duration of remission of psoriasis: a randomized study

Area of Science:

• Dermatology
• Photomedicine

Background:

• Ultraviolet B (UVB) phototherapy is a common treatment for extensive or treatment-resistant psoriasis.
• The optimal duration of UVB therapy after initial disease clearing is not well-established.

Purpose of the Study:

• To compare remission durations in psoriasis patients undergoing maintenance UVB phototherapy versus those discontinuing treatment shortly after clearing.

Main Methods:

• Prospective randomized clinical trial conducted across four university centers.
• Life table methods were used to assess time to flare after initial clearing.

Main Results:

• Patients receiving continued UVB maintenance therapy experienced significantly longer remission times compared to those who discontinued UVB within three weeks of clearing.
• Continuing UVB phototherapy after initial clearing demonstrated a significant benefit in prolonging disease control.

Conclusions:

• Maintenance UVB phototherapy after achieving initial clearing of psoriasis contributes to sustained disease control.
• Continuing UVB treatment is a justified strategy for managing psoriasis and extending remission periods for many patients.