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Induced changes in intracranial pressure in the anesthetized rat and rabbit | JoVE Visualize

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Induced changes in intracranial pressure in the anesthetized rat and rabbit

T J Malkinson, K E Cooper, W L Veale

Brain Research Bulletin|September 1, 1985

View abstract on PubMed

Summary

This study measured intracranial pressure (ICP) in rats and rabbits using a subarachnoid screw technique. Various substances were administered to understand their effects on ICP and cerebrospinal fluid dynamics.

Area of Science:

Neuroscience
Physiology

Background:

Intracranial pressure (ICP) regulation is crucial for brain health.
Understanding cerebrospinal fluid (CSF) dynamics is key to managing neurological conditions.

Purpose of the Study:

To continuously measure ICP in anesthetized rats and rabbits.
To investigate the effects of volume changes and various pharmacological agents on ICP.

Main Methods:

Subarachnoid screw technique for continuous ICP measurement.
Infusion of artificial CSF to alter intracranial volume.
Intravenous administration and inhalation of various agents in rats.
Specific agent administration in rabbits.

Main Results:

Demonstrated elastic and compensatory aspects of CSF dynamics.
Detailed the effects of numerous agents (e.g., urea, epinephrine, CO2) on ICP.
Validated the subarachnoid screw technique for ICP monitoring.

Conclusions:

The subarachnoid screw technique is effective for ICP measurement.
Various interventions significantly alter ICP, providing insights into cerebrovascular regulation.
Results contribute to understanding CSF dynamics and potential therapeutic targets.

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Induced Changes In Intracranial Pressure In The Anesthetized Rat And Rabbit