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[Pharmacologic analysis of the cholinergic vasodilation in unanesthetized animals] | JoVE Visualize

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[Pharmacologic analysis of the cholinergic vasodilation in unanesthetized animals]

Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova|July 1, 1978

View abstract on PubMed

Summary

Hypothalamic stimulation in cats causes cholinergic vasodilation linked to motor activity, not emotions. Central alpha-adrenergic systems activate this response, which is modulated by tranquilizers like reserpine and catapresan.

Area of Science:

Neuroscience
Autonomic Nervous System Research
Cardiovascular Physiology

Background:

Cholinergic vasodilation is a key autonomic response.
The hypothalamus plays a crucial role in regulating cardiovascular functions.
Understanding the central control of vasodilation is vital for managing blood pressure.

Purpose of the Study:

To investigate the brain regions involved in hypothalamic cholinergic vasodilation.
To determine the influence of tranquilizers on this vasodilation.
To elucidate the central nervous system (CNS) mechanisms activating cholinergic vasodilation.

Main Methods:

Electrical stimulation of hypothalamic areas in feline models.
Administration of various tranquilizers (reserpine, catapresan, diazepam).
Monitoring of cardiovascular responses and muscle activity.

Main Results:

Cholinergic vasodilation was elicited by stimulating both emotional and motor hypothalamic areas.
Reserpine decreased, catapresan increased, and diazepam had no effect on vasodilation amplitude.
Vasodilation was correlated with skeletal muscle activity, not emotional responses.
Alpha-adrenergic CNS structures were identified as the activating mechanism for central integration.

Conclusions:

Hypothalamic cholinergic vasodilation is modulated by motor activity and influenced by specific tranquilizers.
Central alpha-adrenergic pathways are essential for integrating this cardiovascular response.
Findings suggest a dissociation between emotional and motor influences on cholinergic vasodilation.

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[pharmacologic Analysis Of The Cholinergic Vasodilation In Unanesthetized Animals]