ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Inherited structural variation and linkage relationships of C7 | JoVE Visualize

Home
Research Domains
Physical Sciences

Inherited structural variation and linkage relationships of C7

M J Hobart, V Joysey, P J Lachmann

Journal of Immunogenetics|June 1, 1978

View abstract on PubMed

Summary

Three structural forms of complement C7 protein were identified using isoelectric focusing. These forms result from co-dominant alleles at an autosomal locus, C7, located near the C6 locus but distant from the HLA complex.

Area of Science:

Biochemistry
Genetics
Immunology

Background:

Complement C7 (C5b-9) is a crucial component of the terminal pathway of the complement system.
Genetic polymorphisms in complement proteins can influence immune response and disease susceptibility.

Purpose of the Study:

To investigate the structural heterogeneity of human complement C7 protein.
To determine the genetic basis and chromosomal location of the C7 locus.

Main Methods:

Isoelectric focusing (IEF) was employed to separate and identify different structural forms of C7.
Genetic linkage analysis was performed to determine the locus of C7 relative to other genetic markers.

Main Results:

Three distinct structural variants of C7 were identified through isoelectric focusing.
These variants are encoded by three co-dominantly expressed alleles at a single autosomal locus, designated C7.
The C7 locus was found to be genetically linked to the C6 locus but not to the HLA complex.

Conclusions:

Human complement C7 exhibits genetic polymorphism with at least three common alleles.
The C7 locus is situated on an autosome near the C6 locus, providing insights into the organization of complement genes.

Condensed Matter Physics

Structural Properties Of Condensed Matter

Inherited Structural Variation And Linkage Relationships Of C7