An outbreak of naphthalene di-isocyanate-induced asthma in a plastics factory

Area of Science:

• Occupational Health
• Industrial Hygiene
• Toxicology

Background:

• Occupational asthma is a significant workplace health concern.
• Isocyanates are known respiratory sensitizers.
• Naphthalene di-isocyanate is used in plastic manufacturing.

Observation:

• Seven cases of possible naphthalene di-isocyanate-related occupational asthma were reported between 1987 and 1988.
• Cases originated from a Midwest factory producing plastic wheels for fork-lift trucks.
• Reports were made to the National Institute for Occupational Safety and Health.

Findings:

• A workplace evaluation, including medical screening, was initiated to identify further cases.
• An industrial-hygiene survey was conducted to assess worker exposure to isocyanates.
• The study aimed to confirm the link between naphthalene di-isocyanate exposure and asthma symptoms.

Implications:

• Findings highlight the need for stringent exposure controls for isocyanates in manufacturing.
• Early detection and medical surveillance are crucial for managing occupational asthma.
• This case series underscores the importance of reporting potential occupational health hazards.