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[Biological compatibility of soft contact lens materials (HEMA) (author's transl)] | JoVE Visualize

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[Biological compatibility of soft contact lens materials (HEMA) (author's transl)]

Klinische Monatsblatter Fur Augenheilkunde|September 1, 1977

View abstract on PubMed

Summary

Soft contact lens materials implanted in rabbit eyes caused periodic iris inflammation and granulomas. The HEMA toxin in these lenses is responsible for these adverse reactions, which are more severe than with PMMA.

Area of Science:

Ophthalmology
Biomaterials Science
Toxicology

Context:

Soft contact lenses are widely used for vision correction.
Understanding the biocompatibility of contact lens materials is crucial for patient safety.
Previous studies have indicated potential adverse reactions to certain lens components.

Purpose:

To evaluate the ocular tissue response to soft contact lens materials implanted in the anterior chamber of rabbit eyes.
To identify the specific components responsible for observed inflammatory reactions.
To compare the biocompatibility of soft contact lens materials with polymethyl methacrylate (PMMA).

Summary:

Discs of soft contact lens materials (Soflens, Hydroflex, Hydron) were implanted in rabbit anterior chambers for six months.
Periodic hyperemia iridis and foreign-substance granulomas were observed at the iris contact site.
A toxin present in HEMA (hydroxyethyl methacrylate) was identified as the cause of these reactions, which were more intense than those seen with PMMA.

Impact:

This study highlights the potential toxicity of HEMA in soft contact lens materials.
Findings suggest a need for improved HEMA purification or alternative biomaterials to minimize ocular inflammation.
Results provide valuable insights for the development of safer contact lens formulations.

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[biological Compatibility Of Soft Contact Lens Materials (hema) (author's Transl)]